Geetha A, Catherine J, Sankar R, Devi C S
Department of Biochemistry, University of Madras, India.
Indian J Exp Biol. 1990 Nov;28(11):1071-4.
The effect of doxorubicin (DXR) on the levels of heart, liver and plasma lipids and plasma lipoproteins were studied in rats. Rats were treated with DXR (2.5 mg/kg body weight weekly for 8 weeks, iv) with or without alpha-tocopherol (alpha-TPL) (400 mg/kg body wt daily for 60 days) co-administration. DXR treated rats showed increase in plasma total cholesterol, triglycerides and phospholipids. The activities of lecithin cholesterol-acyl transferase and hepatic and extrahepatic lipoprotein lipase were lowered significantly with concomitant increase in liver and heart lipid peroxide levels in DXR treatment. HDL cholesterol level was found to be decreased significantly in DXR treated rats as a result of which there was an increase of LDLc/HDLc ratio. alpha-TPL coadministration brought back the enzyme activity to near normal and reduced the level of lipid peroxides. The lipid changes were minimum in rats treated with both alpha-TPL and DXR. This study suggests that the toxicity of DXR is reflected in lipids and lipoprotein profile.
研究了阿霉素（DXR）对大鼠心脏、肝脏和血浆脂质水平以及血浆脂蛋白的影响。将大鼠分为两组，一组静脉注射DXR（2.5毫克/千克体重，每周一次，共8周），另一组在注射DXR的同时联合给予α-生育酚（α-TPL）（400毫克/千克体重，每日一次，共60天）。接受DXR治疗的大鼠血浆总胆固醇、甘油三酯和磷脂水平升高。在DXR治疗组中，卵磷脂胆固醇酰基转移酶以及肝脏和肝外脂蛋白脂肪酶的活性显著降低，同时肝脏和心脏脂质过氧化物水平升高。发现接受DXR治疗的大鼠高密度脂蛋白胆固醇水平显著降低，导致低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值升高。联合给予α-TPL可使酶活性恢复至接近正常水平，并降低脂质过氧化物水平。在同时接受α-TPL和DXR治疗的大鼠中，脂质变化最小。这项研究表明，DXR的毒性反映在脂质和脂蛋白谱中。
