INQUINOA-CONICET, Cátedra de Fisicoquímica I, Instituto de Química Física, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Lorenzo 456, T4000CAN S. M. de Tucumán, Argentina.
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov;97:479-89. doi: 10.1016/j.saa.2012.06.045. Epub 2012 Jul 3.
The present study is a first step towards the investigation of S-methyl methanethiosulfonate (MMTS) interaction with membrane model systems like liposomes. In this paper, the interaction of MMTS with dipalmitoylphosphatidylcholine (DPPC) bilayers was studied by FTIR and SERS spectroscopy. Lysolipid effect on vesicle stability was studied. The results show that MMTS interacts to different extents with the phosphate and carbonyl groups of membranes in the gel and the liquid crystalline states. To gain a deeper insight into MMTS properties that may be potentially helpful in the design of new drugs with therapeutic effects, we performed theoretical studies that may be the basis for the design of their mode of action.
本研究是探索 S-甲基甲硫磺酸酯（MMTS）与脂质体等膜模型系统相互作用的第一步。本文采用傅里叶变换红外光谱（FTIR）和表面增强拉曼散射光谱（SERS）研究了 MMTS 与二棕榈酰磷脂酰胆碱（DPPC）双层膜的相互作用。研究了溶血磷脂对囊泡稳定性的影响。结果表明，MMTS 在凝胶态和液晶态下与膜的磷酸基和羰基以不同的程度相互作用。为了更深入地了解 MMTS 的特性，这些特性可能有助于设计具有治疗效果的新药，我们进行了理论研究，这些研究可能为其作用模式的设计提供基础。
