Magnani Jared W, Newton-Cheh Christopher, O'Donnell Christopher J, Levy Daniel
National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
J Electrocardiol. 2012 Nov-Dec;45(6):673-6. doi: 10.1016/j.jelectrocard.2012.06.016. Epub 2012 Jul 24.
The electrocardiogram (ECG) has widespread use in clinical care and research. Despite its extensive use and study, important gaps remain in examining prospective, repeated longitudinal ECG measures, and their association with cardiovascular outcomes. The Framingham Heart Study (FHS) is a community-based study designed to examine risk factors and outcomes associated with cardiovascular disease. Here, we describe a novel effort in the FHS to develop a unique resource: serial ECGs conducted on 3 generations of study participants spanning multiple decades (1986 to the present). We describe the FHS and the role the ECG has had in conducting cardiovascular epidemiology in the FHS. We then describe potential applications for a longitudinal ECG repository. We expect the Framingham ECG repository to enhance cardiovascular research and epidemiologic study. Such a resource will complement the phenotypic and genotypic characterization of FHS, facilitating novel investigations of cardiovascular epidemiology.
心电图（ECG）在临床护理和研究中有着广泛应用。尽管其应用广泛且研究众多，但在检查前瞻性、重复的纵向心电图测量及其与心血管结局的关联方面仍存在重要空白。弗雷明汉心脏研究（FHS）是一项基于社区的研究，旨在检查与心血管疾病相关的危险因素和结局。在此，我们描述了FHS中的一项新举措，即开发一种独特资源：对跨越数十年（1986年至今）的三代研究参与者进行系列心电图检查。我们描述了FHS以及心电图在FHS开展心血管流行病学研究中所起的作用。然后我们描述了纵向心电图库的潜在应用。我们期望弗雷明汉心电图库能加强心血管研究和流行病学研究。这样一种资源将补充FHS的表型和基因型特征，促进心血管流行病学的新研究。
