Department of Infectious Diseases, Azienda Universitaria San Giovanni di Dio e Ruggi d'Aragona, Largo Città di Ippocrate, 84131 Salerno, Italy.
J Antimicrob Chemother. 2012 Nov;67(11):2570-5. doi: 10.1093/jac/dks277. Epub 2012 Jul 24.
Despite the large number of suggestions available in the literature, the optimal duration of antibiotic treatment remains an individual decision mainly based on clinical criteria. Shorter but equally effective regimens would reduce the side effect rates, including both antibiotic resistance and drug expenses. Although several prospective, randomized trials and meta-analyses with the aim of comparing a standard duration with a shorter one for most bacterial infections have been published, to date most current recommendations carry little weight, as they are based on expert opinions or practical experience. This review will briefly touch upon the clinical evidence of short-course versus long-course antibiotic therapy for the most common community- and hospital-acquired bacterial infections.
尽管文献中有大量的建议，但抗生素治疗的最佳持续时间仍然是一个主要基于临床标准的个人决定。更短但同样有效的方案将降低副作用发生率，包括抗生素耐药性和药物费用。尽管已经发表了几项旨在比较大多数细菌感染的标准疗程和更短疗程的前瞻性、随机试验和荟萃分析，但迄今为止，大多数现行建议的权重较小，因为它们是基于专家意见或实际经验。这篇综述将简要介绍短期与长期抗生素治疗最常见的社区和医院获得性细菌感染的临床证据。
