Department of Veterinary Basic Sciences, The Royal Veterinary College, London, UK.
Front Endocrinol (Lausanne). 2012 Jul 20;3:88. doi: 10.3389/fendo.2012.00088. eCollection 2012.
The phosphoinositide 3-kinase and AKT (protein kinase B) signaling pathway (PI3K/AKT) plays a central role in the control of cell survival, growth, and proliferation throughout the body. With regard to bone, and particularly in osteoblasts, there is an increasing amount of evidence that the many signaling molecules exert some of their bone-specific effects in part via selectively activating some of the generic effects of the PI3K/AKT pathway in osteoblasts. There is further data demonstrating that PI3K/AKT has the capacity to specifically cross-talk with other signaling pathways and transcriptional networks controlling bone cells' development in order to fine-tune the osteoblast phenotype. There is also evidence that perturbations in the PI3K/AKT pathway may well be responsible for certain bone pathologies. In this review, we discuss some of these findings and suggest that the PI3K/AKT pathway is a central nexus in the extensive network of extracellular signaling pathways that control the osteoblast.
磷酸肌醇 3-激酶和 AKT（蛋白激酶 B）信号通路（PI3K/AKT）在全身细胞存活、生长和增殖的控制中起着核心作用。就骨骼而言，特别是在成骨细胞中，越来越多的证据表明，许多信号分子通过选择性地激活成骨细胞中 PI3K/AKT 通路的某些通用效应，在一定程度上发挥其骨骼特异性效应。还有进一步的数据表明，PI3K/AKT 能够与其他信号通路和转录网络进行特异性交叉对话，以控制骨细胞的发育，从而精细调节成骨细胞表型。也有证据表明，PI3K/AKT 通路的扰动可能是某些骨骼病理学的原因。在这篇综述中，我们讨论了其中的一些发现，并提出 PI3K/AKT 通路是控制成骨细胞的广泛细胞外信号通路网络中的一个中心枢纽。
