Fetherston Susan M, Malcolm R Karl, Woolfson A David
School of Pharmacy, 97 Lisburn Road, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland, UK.
Ther Deliv. 2010 Dec;1(6):785-802. doi: 10.4155/tde.10.74.
Over half of all HIV-infected adults are women and heterosexual intercourse is a significant mode of viral transmission. This review examines the potential for using polymeric vaginal ring systems to provide controlled delivery of HIV microbicides in order to prevent heterosexual transmission of the virus.
Continuous delivery of microbicides has the potential to be more effective than one-off dosing. Thus, controlled-release vaginal delivery devices are now a key area of HIV prevention research. Initial clinical trials on vaginal rings loaded with dapivirine (a candidate microbicide) have indicated that these products are safe and well tolerated by women. These devices are female-initiated, robust and capable of long-term delivery of the active agent.
Vaginal rings may offer an effective system for the controlled delivery of microbicides to prevent heterosexual transmission of HIV. Candidate vaginal ring microbicide products are now in clinical trials.
超过半数的成年HIV感染者为女性，异性性行为是病毒传播的重要途径。本综述探讨了使用聚合物阴道环系统来控制递送HIV杀微生物剂以预防该病毒异性传播的可能性。
持续递送杀微生物剂可能比一次性给药更有效。因此，控释阴道给药装置现已成为HIV预防研究的关键领域。对载有达匹韦林（一种候选杀微生物剂）的阴道环进行的初步临床试验表明，这些产品安全且女性耐受性良好。这些装置由女性自主使用，耐用且能够长期递送活性剂。
阴道环可能为控制递送杀微生物剂以预防HIV异性传播提供一种有效的系统。候选阴道环杀微生物剂产品目前正在进行临床试验。
