将基因检测用作预测指标的系统评价中的挑战与原则
Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators
作者信息
Jonas Daniel E, Wilt Timothy J, Taylor Brent C, Wilkins Tania M, Matchar David B
机构信息
University of North Carolina
Department of Veterans Affairs Health Care System, Minneapolis; University of Minnesota
In this chapter we discuss common challenges in and principles for conducting systematic reviews of genetic tests. The types of genetic tests discussed are those used to (1) determine risk or susceptibility in asymptomatic individuals; (2) reveal prognostic information to guide clinical management in those with a condition; or (3) predict response to treatments or environmental factors. This chapter is not intended to provide comprehensive guidance on evaluating all genetic tests. Rather, it focuses on issues that have been of particular concern to analysts and stakeholders and on areas that are of particular relevance for the evaluation of studies of genetic tests.
在本章中，我们将讨论对基因检测进行系统评价时面临的常见挑战和原则。所讨论的基因检测类型包括用于：（1）确定无症状个体的风险或易感性；（2）揭示预后信息以指导患有某种疾病的个体的临床管理；或（3）预测对治疗或环境因素的反应。本章并非旨在提供评估所有基因检测的全面指导。相反，它侧重于分析人员和利益相关者特别关注的问题，以及与基因检测研究评估特别相关的领域。
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