Cardiovascular Research Institute and Department of Cardiology, Shenyang Northern Hospital, 83 Wenhua Road, 110840 Shenyang, China.
Curr Mol Med. 2012 Dec;12(10):1273-81. doi: 10.2174/156652412803833526.
Cellular repressor of E1A-stimulated genes (CREG), a novel cellular protein, was discovered in 1998. Accumulating evidence, mainly from our laboratory, has suggested that CREG plays critical roles in reducing neointimal hyperplasia, maintaining vascular homeostasis, and promoting endothelial restoration. The study of CREG has the potential to offer new insights into both prevention and treatment of proliferative vascular disease, and will help us understand the processes of vascular repair after injury. It will also contribute to the development of new therapeutic strategies and devices, such as anti-in-stent restenosis stents. The present review summarizes our research on the molecular identity of CREG, and reviews the biological activities of CREG in regulating cell differentiation, proliferation, migration, and apoptosis of vascular smooth muscle cells and endothelial cells.
细胞 E1A 刺激基因的抑制剂（CREG）是一种新的细胞蛋白，于 1998 年被发现。越来越多的证据，主要来自我们的实验室，表明 CREG 在减少新生内膜增生、维持血管稳态和促进内皮修复方面发挥着关键作用。对 CREG 的研究有可能为增殖性血管疾病的预防和治疗提供新的见解，并帮助我们了解损伤后血管修复的过程。它也将有助于开发新的治疗策略和设备，如抗再狭窄支架。本综述总结了我们对 CREG 分子特性的研究，并回顾了 CREG 调节血管平滑肌细胞和内皮细胞的细胞分化、增殖、迁移和凋亡的生物学活性。
