Center for Catalysis, Department of Chemistry, Aarhus University , DK-8000 Aarhus C, Denmark.
J Am Chem Soc. 2012 Aug 8;134(31):12943-6. doi: 10.1021/ja3068269. Epub 2012 Jul 30.
Cross-conjugated trienamines are introduced as a new concept in asymmetric organocatalysis. These intermediates are applied in highly enantioselective Diels-Alder and addition reactions, providing functionalized bicyclo[2.2.2]octane compounds and γ'-addition products, respectively. The nature of the transformations and the intermediates involved are investigated by computational calculations and NMR analysis.
交叉共轭三烯胺作为不对称有机催化中的新概念被引入。这些中间体被应用于高对映选择性的 Diels-Alder 和加成反应，分别提供官能化的双环[2.2.2]辛烷化合物和γ'-加成产物。通过计算计算和 NMR 分析研究了转化的性质和涉及的中间体。
