夏伊-德雷格综合征。氟氢可的松和L-苏式-3,4-二羟基苯丝氨酸对血压和局部脑血流量的影响。
Shy-Drager syndrome. Effect of fludrocortisone and L-threo-3,4-dihydroxyphenylserine on the blood pressure and regional cerebral blood flow.
作者信息
Matsubara S, Sawa Y, Yokoji H, Takamori M
机构信息
Department of Neurology, Kanazawa University School of Medicine, Japan.
出版信息
J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):994-7. doi: 10.1136/jnnp.53.11.994.
Abstract
In nine cases of Shy-Drager syndrome, the changes in blood pressure and cerebral blood flow on sitting up from a supine position were studied. The influence of fludrocortisone, a synthetic mineralocorticoid, and L-threo-3,4-dihydroxyphenylserine (DOPS), a precursor of norepinephrine, on these changes was examined. On sitting up, the regional cerebral blood flow (rCBF) measured by Xe133 inhalation showed a tendency to decrease. Fludrocortisone reduced the fall of the mean blood pressure significantly. DOPS reduced the fall of both the diastolic blood pressure and rCBF significantly.
摘要
对9例夏伊-德雷格综合征患者，研究了从仰卧位坐起时血压和脑血流量的变化。研究了合成盐皮质激素氟氢可的松和去甲肾上腺素前体L-苏式-3,4-二羟基苯丝氨酸（DOPS）对这些变化的影响。坐起时，通过吸入Xe133测量的局部脑血流量（rCBF）有下降趋势。氟氢可的松显著降低平均血压的下降幅度。DOPS显著降低舒张压和rCBF的下降幅度。
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Shy-Drager syndrome. Effect of fludrocortisone and L-threo-3,4-dihydroxyphenylserine on the blood pressure and regional cerebral blood flow.夏伊-德雷格综合征。氟氢可的松和L-苏式-3,4-二羟基苯丝氨酸对血压和局部脑血流量的影响。
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