Simmonds N J, Hoffbrand B I
Whittington Hospital, London, United Kingdom.
J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):998-1000. doi: 10.1136/jnnp.53.11.998.
Granulomatous muscle disease is most commonly seen in sarcoidosis, but may be seen in association with a wide variety of other disorders or in isolation. Patients with granulomatous myositis usually present with slowly progressive muscle pain and weakness affecting mainly proximal muscles. There are, however, a few reports of granulomatous muscle disease presenting with flexion contractures of the limbs. Two further patients with granulomatous muscle disease and flexion contractures of the limbs, but with no evidence of systemic granulomatous disease, is presented. It is suggested that such patients represent a separate clinical entity that is distinct from idiopathic granulomatous myositis presenting with muscle pain and weakness. The association of contracturing granulomatous myositis with a long-standing vasculitis in one patient suggests that the two conditions may be related.
肉芽肿性肌病最常见于结节病，但也可能与多种其他疾病相关或单独出现。肉芽肿性肌炎患者通常表现为缓慢进展的肌肉疼痛和无力，主要影响近端肌肉。然而，有少数关于肉芽肿性肌病表现为肢体屈曲挛缩的报道。本文介绍了另外两名患有肉芽肿性肌病和肢体屈曲挛缩但无全身肉芽肿性疾病证据的患者。提示此类患者代表一种独立的临床实体，有别于表现为肌肉疼痛和无力的特发性肉芽肿性肌炎。一名患者的挛缩性肉芽肿性肌炎与长期血管炎相关，提示这两种情况可能有关联。
