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老年二尖瓣手术。

Mitral valve surgical procedures in the elderly.

机构信息

Department of Cardiac Surgery, University Heart Center Leipzig, Germany.

出版信息

Ann Thorac Surg. 2012 Dec;94(6):1999-2003. doi: 10.1016/j.athoracsur.2012.05.069. Epub 2012 Jul 25.

Abstract

BACKGROUND

Mitral valve (MV) surgical procedures in the elderly are associated with profound operative and long-term mortality. We report our experience and results for MV surgical procedures in the elderly, especially with regard to the influence of comorbidities.

METHODS

Our hospital database was assessed to identify all patients who underwent MV surgical procedures at the age of 70 years and older between 1999 and 2009. The data were retrospectively analyzed.

RESULTS

A total of 2,503 patients operated on during this 10-year period were identified. In 97% of patients, mitral regurgitation (MR) was the primary indication for operation, followed by coronary artery disease in 41.6% and aortic valve stenosis in 21.3%. The 30-day mortality rate was 3.1%, and the long-term survival at 5 years was 55.2% (95% confidence interval, 52.3% to 57.5%). Coronary artery bypass grafting was identified to be associated with inferior short-term and long-term survival. Numerous comorbidities significantly influenced long-term survival. The observed mortality was significantly lower than predicted by EuroSCORE (17.2%).

CONCLUSIONS

MV operations in the elderly can be performed with a low early mortality and promising long-term survival. However, our large series demonstrates that comorbidities are to be attributed as the real burden for successful treatment of elderly patients undergoing MV procedures.

摘要

背景

老年人心动瓣膜(MV)手术与显著的手术和长期死亡率相关。我们报告了我们在老年人心动瓣膜手术方面的经验和结果,特别是关于合并症影响的结果。

方法

我们评估了医院数据库,以确定在 1999 年至 2009 年间,70 岁及以上接受 MV 手术的所有患者。对数据进行了回顾性分析。

结果

在这 10 年期间,共确定了 2503 名接受手术的患者。在 97%的患者中,二尖瓣反流(MR)是手术的主要指征,其次是 41.6%的冠状动脉疾病和 21.3%的主动脉瓣狭窄。30 天死亡率为 3.1%,5 年生存率为 55.2%(95%置信区间为 52.3%至 57.5%)。冠状动脉旁路移植术与短期和长期生存不良相关。许多合并症显著影响长期生存。观察到的死亡率明显低于 EuroSCORE 预测的死亡率(17.2%)。

结论

老年人心动瓣膜手术可获得低早期死亡率和有希望的长期生存率。然而,我们的大型系列研究表明,合并症是成功治疗老年人心动瓣膜手术患者的真正负担。

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