Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 1 Meedan Elkhartoom, Alexandria 21521, Egypt.
Eur J Med Chem. 2012 Sep;55:85-93. doi: 10.1016/j.ejmech.2012.07.007. Epub 2012 Jul 14.
Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium.
一些新的取代噻吩并嘧啶衍生物，包括噻噁、硫代烷基和吡唑基衍生物，以及稠合的噻吩并三唑并嘧啶和噻吩并嘧啶并三嗪环系统，是由 3-苄基-2-肼基-5-甲基-4-氧代-3,4-二氢噻吩并[2,3-d]嘧啶-6-甲酰胺 4 制备的。设计的化合物被评估了其抗炎活性。与参考药物双氯芬酸钠相比，化合物 4、9、10 和 13 表现出最高的抗炎效果。
