The Brain Institute, University of Utah, Salt Lake City, UT, United States.
Psychiatry Res. 2012 Jun 30;202(3):224-32. doi: 10.1016/j.pscychresns.2011.11.005. Epub 2012 Jul 24.
There are currently no studies that have evaluated the motor network, including the cerebellum, in adolescent marijuana (MJ) smokers. The current study aimed to evaluate whether there were activation differences in Brodmann's area 4 (BA4), Brodmann's area 6 (BA6), cingulate (CG) and cerebellum between MJ-using adolescents and healthy controls (HC) on a functional magnetic resonance imaging (fMRI) bilateral finger-tapping task. Twenty-four adolescents (aged 18.2 ± 0.7 years) with heavy MJ use and 24 HC (18.0 ± 1.9) had MRI scans on a 3T Siemens scanner, including a standard bilateral fMRI finger-tapping sequence. Imaging data were analyzed using SPM5 in Matlab. As regions of interest, BA4, BA6, cingulate (CG) and cerebellum were selected, and significant clusters of activity were thresholded at p<0.05, corrected. Healthy controls had significantly greater activation than MJ users for the CG and cerebellum. In addition, activation of the cerebellum and CG correlated with lifetime MJ smokes. This is one of the first studies to evaluate cortico-cerebellar circuits in adolescents with heavy MJ use. The study, which used a bilateral finger-tapping fMRI task, provides evidence for both CG and cerebellar dysfunction in MJ abuse and indicates that lifetime MJ use may impact the developing brain.
目前尚无研究评估青少年吸食大麻（MJ）者的运动网络，包括小脑。本研究旨在评估在功能磁共振成像（fMRI）双侧手指敲击任务中，MJ 使用青少年和健康对照（HC）之间 Brodmann 区 4（BA4）、Brodmann 区 6（BA6）、扣带回（CG）和小脑是否存在激活差异。24 名重度 MJ 使用青少年（18.2±0.7 岁）和 24 名 HC（18.0±1.9）在 3T 西门子扫描仪上进行 MRI 扫描，包括标准双侧 fMRI 手指敲击序列。使用 Matlab 中的 SPM5 对成像数据进行分析。选择 BA4、BA6、CG 和小脑作为感兴趣区，并对活动的显著簇进行 p<0.05 的阈值校正。与 MJ 用户相比，HC 具有明显更高的 CG 和小脑激活。此外，小脑和 CG 的激活与终生 MJ 吸烟量相关。这是第一项评估重度 MJ 使用青少年皮质小脑回路的研究之一。该研究使用双侧手指敲击 fMRI 任务，为 MJ 滥用中的 CG 和小脑功能障碍提供了证据，并表明终生 MJ 使用可能会影响发育中的大脑。
