Department of Laboratory Diagnostic and Clinical Immunology of Developmental Age, Warsaw Medical University, Warsaw, Poland.
Adv Exp Med Biol. 2013;756:1-8. doi: 10.1007/978-94-007-4549-0_1.
NETosis is a unique death pathway that differs from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) by NADPH oxidase. During this process, neutrophil extracellular traps (NETs) are created. NETs are extracellular structures composed of chromatin and variety of proteins from cells granules that bind and kill microorganisms. Recently, novel functions of NET have been proposed. It seems that neutrophil traps play an essential role during autoimmunity. They can induce and exacerbate diseases based on immune system malfunction.
NETosis 是一种独特的细胞死亡途径，不同于细胞凋亡和细胞坏死，它依赖于 NADPH 氧化酶产生的活性氧（ROS）。在此过程中，会产生中性粒细胞胞外诱捕网（NETs）。NETs 是由染色质和来自细胞颗粒的多种蛋白质组成的细胞外结构，可结合并杀死微生物。最近，NET 的新功能被提出。似乎中性粒细胞陷阱在自身免疫中起着至关重要的作用。它们可以基于免疫系统功能障碍而引发和加重疾病。
