Nakazawa S, Sato H, Narita A, Nakazawa S, Suzuki H, Matsumoto K, Nakanishi Y, Niino K
Department of Pediatrics, Tokyo Ebara Municipal Hospital.
Jpn J Antibiot. 1990 Aug;43(8):1450-61.
Cefdinir (CFDN, FK482) granules, a new oral antibiotic for children, were given to children with infections. The results obtained are summarized as follows. 1. The plasma level of CFDN peaked at 0.38-0.88 microgram/ml in 2-3 hours after administration of the drug at a dose of 3 mg/kg. Meanwhile, the plasma level peaked at 1.85 micrograms/ml in 3 hours after administration of 6 mg/kg. The plasma level was higher in the 6 mg/kg group than that in the 3 mg/kg group, thus a dose response was clearly observed. 2. The 8 hour urinary excretion accounted for 10.3-17.4% of administered amount of the drug in children with 3-6 mg/kg dosage. 3. CFDN granules were administered to a total of 42 children with upper or lower airway infections or with urinary tract infections at daily doses of 9.0-20.7 mg/kg in 3 divided portions. The clinical efficacy was "excellent" in 28 patients, "good" in 13, and "fair" in 1, hence an efficacy rate of 97.6% was obtained. 4. Bacteria identified from various diseases were 29 strains of 9 species, and the eradication rate was 82.8%. 5. No. side effects were noted in any of the children. Laboratory test results showed an abnormality in 1 case each with a rise of platelet count and eosinophilia.
头孢地尼（CFDN，FK482）颗粒是一种新型儿童口服抗生素，用于治疗儿童感染。获得的结果总结如下。1. 以3mg/kg的剂量给药后，CFDN的血浆水平在2 - 3小时达到峰值，为0.38 - 0.88微克/毫升。同时，以6mg/kg给药后，血浆水平在3小时达到峰值，为1.85微克/毫升。6mg/kg组的血浆水平高于3mg/kg组，因此明显观察到剂量反应。2. 对于剂量为3 - 6mg/kg的儿童，8小时尿排泄量占给药量的10.3 - 17.4%。3. 总共42名患有上呼吸道或下呼吸道感染或尿路感染的儿童服用了CFDN颗粒，每日剂量为9.0 - 20.7mg/kg，分3次服用。临床疗效为“优”的有28例，“良”的有13例，“中”的有1例，因此有效率为97.6%。4. 从各种疾病中鉴定出的细菌有9个菌种的29株，根除率为82.8%。5. 所有儿童均未出现副作用。实验室检查结果显示，各有1例出现血小板计数升高和嗜酸性粒细胞增多的异常情况。
