Mironov V I, Serkina A V, Zabrodina L V, Duganova V V, Pekerskiĭ I E
Khirurgiia (Mosk). 1990 Oct(10):105-8.
Experimental data are discussed and experience in complex treatment of 102 patients with acute pancreatitis with the application of intralesional+ electrophoresis is analysed. It was demonstrated in experiments on 90 albino rats that in intralesional+ electrophoresis of radioactive++ 5-fluorouracil (5-FU), its concentration in the pancreas was 2.4-3-fold that in the group of animals in which only intraperitoneal injections of the agent were given. Intralesional+ 5-FU, antibiotic, and contrykal electrophoresis was applied in the clinic in 75 patients with edematous and in 27 patients with destructive pancreatitis. Intralesional+ electrophoresis had a favourable effect on the course of acute pancreatitis, but its efficacy was lower in destructive pancreatitis. Intralesional+ electrophoresis made it possible to lower the general therapeutic doses of these agents and to reduce the number of injections per 24 hours. Three fatal outcomes occurred.
讨论了实验数据，并分析了应用病灶内+电泳对102例急性胰腺炎患者进行综合治疗的经验。在90只白化大鼠的实验中表明，在放射性++5-氟尿嘧啶（5-FU）的病灶内+电泳中，其在胰腺中的浓度是仅给予该药物腹腔注射的动物组中的2.4至3倍。病灶内+5-FU、抗生素和抑肽酶电泳应用于75例水肿性胰腺炎患者和27例坏死性胰腺炎患者的临床治疗。病灶内+电泳对急性胰腺炎的病程有良好影响，但其在坏死性胰腺炎中的疗效较低。病灶内+电泳能够降低这些药物的总体治疗剂量，并减少每24小时的注射次数。发生了3例死亡病例。
