Sokolov L K, Nikiforov P A, Vasil'ev I D, Gul'kevich K Iu, Sklianskaia O A, Iarushnikov K Iu
Klin Med (Mosk). 1990 Nov;68(11):108-11.
Visual assessment of gastric mucosa and histological findings in biopsies from the lesions were compared for 1806 patients with chronic atrophic gastritis. The spectrum of the focal lesions appeared wide. Morphological examinations determined basic comparable structural elements typical for atrophic gastritis. 85 patients were diagnosed to have early gastric cancer. All the cancer patients suffered from chronic atrophic gastritis and developed in 88% of cases intestinal metaplasia, in 32% severe epithelial dysplasia. Focal changes in the mucosa characteristic for early gastric cancer in 64% of cases could be considered as variants of chronic atrophic gastritis. In 52 patients cancer was identified during the follow-up, new-onset macroscopic alterations emerging in the last year in 62% cancer subjects. The rest of them had long-lasting macroscopic lesions, among them severe dysplasia of the epithelium in 65% of cases, believed to be histological variants of atrophic gastritis. Early cancer is suggested to develop in the presence of previous lesions rapidly and discretely.
对1806例慢性萎缩性胃炎患者的胃黏膜进行了视觉评估，并对病变活检的组织学结果进行了比较。局灶性病变的范围似乎很广。形态学检查确定了萎缩性胃炎典型的基本可比结构要素。85例患者被诊断为早期胃癌。所有癌症患者均患有慢性萎缩性胃炎，88%的病例发生肠化生，32%的病例发生重度上皮异型增生。64%的早期胃癌病例中，黏膜的局灶性变化可被视为慢性萎缩性胃炎的变体。在52例患者的随访过程中发现了癌症，62%的癌症患者在去年出现了新的肉眼可见改变。其余患者有长期的肉眼可见病变，其中65%的病例存在上皮重度异型增生，被认为是萎缩性胃炎的组织学变体。提示早期癌症在先前病变存在的情况下迅速且离散地发展。
