Draelos Zoe Diana, Shalita Alan R, Thiboutot Diane, Oresajo Christian, Yatskayer Margarita, Raab Susanna
Department of Dermatology, Duke University School of Medicine, Durham, North Carolina, USA.
Cutis. 2012 Jun;89(6):287-93.
Acne treatment regimens have changed due to the recent over-the-counter (OTC) switch of all prescription benzoyl peroxide (BPO) topical preparations. The elimination of prescription single-agent BPO products means that dermatologists must select from a variety of OTC formulations to utilize the time-tested efficacy of BPO in the treatment of mild to moderate acne. Our research compared the efficacy and safety of an OTC BPO 5.5% formulation with lipohydroxy acid and tretinoin cream 0.025% with prescription clindamycin 1%-BPO 5% gel and tretinoin cream 0.025%. Parity was demonstrated between the 2 treatment regimens at 12 weeks.
由于近期所有处方级过氧化苯甲酰（BPO）外用制剂转为非处方（OTC）药物，痤疮治疗方案发生了变化。处方级单组分BPO产品的淘汰意味着皮肤科医生必须从多种OTC制剂中进行选择，以利用BPO在治疗轻至中度痤疮方面经过时间考验的疗效。我们的研究比较了一种含5.5% BPO的OTC制剂与含0.025%脂羟基酸和维甲酸乳膏与处方级1%克林霉素-5% BPO凝胶和0.025%维甲酸乳膏的疗效和安全性。两种治疗方案在12周时显示出等效性。
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