Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, NY, USA.
Am J Obstet Gynecol. 2012 Nov;207(5):417.e1-6. doi: 10.1016/j.ajog.2012.06.051. Epub 2012 Jun 29.
We sought to determine the prevalence of adenomyosis and assess its effect on lymph node status in endometrioid adenocarcinoma of the endometrium (EAC).
Hysterectomy specimens from a single institution were reviewed for the presence of adenomyosis, lymphovascular space invasion (LVSI), tumor grade, histology, and lymph node status. Standard statistical analysis was used to compare variables.
Adenomyosis was present in 42% of total and 66% of malignant hysterectomy specimens (P = .009). Adenomyosis was most commonly associated with EAC histology (P = .023). LVSI was found to be an independent predictor of lymph node metastasis in EAC patients without adenomyosis, but not in those with coexisting adenomyosis (odds ratio, 58.7; P = .03; and odds ratio, 4.98; P = .15; respectively).
Adenomyosis was associated with a lower risk of lymph node metastasis in EAC patients with LVSI. Further studies are needed to investigate the role of adenomyosis in lymphatic tumor infiltration.
我们旨在确定子宫腺肌病的流行率，并评估其对子宫内膜样腺癌（EAC）淋巴结状态的影响。
对单一机构的子宫切除术标本进行了检查，以确定是否存在子宫腺肌病、淋巴管血管侵犯（LVSI）、肿瘤分级、组织学和淋巴结状态。使用标准统计分析来比较变量。
腺肌病在总标本中占 42%，在恶性子宫切除术标本中占 66%（P =.009）。腺肌病最常与 EAC 组织学相关（P =.023）。LVSI 被发现是 EAC 患者无腺肌病淋巴结转移的独立预测因子，但在伴有共存腺肌病的患者中不是（优势比，58.7；P =.03；和优势比，4.98；P =.15；分别）。
在患有 LVSI 的 EAC 患者中，腺肌病与淋巴结转移风险降低相关。需要进一步研究来探讨腺肌病在淋巴管肿瘤浸润中的作用。
