早孕期母血清白介素-33 和可溶性 ST2 及其与流产的关系。
Maternal serum interleukin-33 and soluble ST2 across early pregnancy, and their association with miscarriage.
机构信息
Translational Obstetrics Group, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia.
出版信息
J Reprod Immunol. 2012 Sep;95(1-2):46-9. doi: 10.1016/j.jri.2012.06.003. Epub 2012 Jul 28.
A shift from type 1 to type 2 immune bias is essential for successful implantation and pregnancy. ST2 is a receptor present on type 2 immune cells and IL-33 was recently discovered to be its ligand. We measured serum levels of soluble ST2 (sST2) and IL-33 across the mid-first trimester and examined whether levels were dysregulated among women with a viable fetus but destined to miscarry. While there was no significant change in sST2 or IL-3 across the first trimester, we found that women with live pregnancies destined to fail had dysregulated levels of serum IL-33, and potentially sST2 at six weeks' gestation.
从 1 型免疫偏向向 2 型免疫偏向的转变对于成功的着床和妊娠至关重要。ST2 是 2 型免疫细胞上的一种受体，最近发现白细胞介素-33（IL-33）是其配体。我们在妊娠早期中期测量了可溶性 ST2（sST2）和白细胞介素-33（IL-33）的血清水平，并研究了其水平在有存活胎儿但注定要流产的女性中是否失调。虽然在妊娠早期 sST2 或 IL-3 没有显著变化，但我们发现注定要失败的活产妊娠妇女血清 IL-33 水平失调，可能在妊娠 6 周时 sST2 水平也失调。
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