School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Neurotoxicology. 2012 Oct;33(5):1248-53. doi: 10.1016/j.neuro.2012.07.004. Epub 2012 Jul 25.
Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.
Wistar 大鼠用咖啡因或 2-溴乙胺处理，用各种 LC-MS 方法研究咖啡因对大鼠血清和组织中半卡巴肼敏感胺氧化酶（SSAO）活性的影响。发现咖啡因给药 10 天后存在于所有组织中，并在 25 天内积累。咖啡因在大脑和肝脏中的含量较高，发现所有组织中的 SSAO 活性均被咖啡因抑制。随着咖啡因浓度的增加，SSAO 活性降低。抑制率与存在的咖啡因水平相关。我们推测咖啡因可能治疗与 SSAO 活性相关的疾病。
