头颈部癌症中的血管周干细胞龛。
Perivascular stem cell niche in head and neck cancer.
机构信息
Department of Cariology, Restorative Sciences and Endodontics, University of Michigan, School of Dentistry, United States.
出版信息
Cancer Lett. 2013 Sep 10;338(1):41-6. doi: 10.1016/j.canlet.2012.07.025. Epub 2012 Jul 25.
Abstract
Cancers may contain a small sub-population of uniquely tumorigenic cells that exhibit self-renewal and multipotency, i.e. cancer stem cells (CSCs). These cells reside in invasive fronts in close proximity to blood vessels in many tumors, including head and neck squamous cell carcinomas (HNSCCs). Recent evidence suggests that CSC resist chemotherapy and "drive" local recurrence and metastatic spread. Notably, endothelial cell-initiated signaling is critical for the survival and self-renewal of CSC and may play a role in resistance to therapy. Therefore, patients with head and neck cancer might benefit from therapies that target the CSC directly or their supportive perivascular niche.
摘要
癌症可能包含一小部分具有独特肿瘤发生能力的细胞亚群，这些细胞表现出自我更新和多能性，即癌症干细胞（CSC）。这些细胞存在于许多肿瘤的侵袭前沿，靠近血管，包括头颈部鳞状细胞癌（HNSCC）。最近的证据表明，CSC 抵抗化疗，并“驱动”局部复发和转移扩散。值得注意的是，内皮细胞启动的信号对于 CSC 的存活和自我更新至关重要，并且可能在治疗抵抗中发挥作用。因此，头颈部癌症患者可能受益于直接针对 CSC 或其支持性血管周龛的治疗。
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