Diakhaté L, Feo C, Buffet C, Tchernia G, Labayle D, Etienne J P
Sem Hop. 1979;55(31-32):1418-21.
The increase in volume of human erythrocytes during chronic alcoholic intoxication and its decrease after alcoholic deprivation was studied with a multichannel analyzer. When fractions of the population of red cells were separated by differential centrifugation the macrocytosis was found to be uniformly distributed. The presence of macrocytes was not related to changes of plasma osmolality or hyperhydration of red cells. A central origin was evoked, however, the role of the folic acid deficiency could not explain the macrocytosis, the mechanism of which remains to be elucidated.
用多通道分析仪研究了慢性酒精中毒期间人体红细胞体积的增加及其在戒酒之后的减少情况。当通过差速离心法分离红细胞群体的各个组分时，发现巨红细胞增多现象呈均匀分布。巨红细胞的存在与血浆渗透压的变化或红细胞的水分过多无关。然而，虽然有人提出是中枢性起源，但叶酸缺乏的作用并不能解释巨红细胞增多现象，其机制仍有待阐明。
