Department of Pharmacology & Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt.
Toxicol Appl Pharmacol. 2012 Oct 1;264(1):84-93. doi: 10.1016/j.taap.2012.07.020. Epub 2012 Jul 25.
Methyl palmitate (MP) and ethyl palmitate (EP) are naturally occurring fatty acid esters reported as inflammatory cell inhibitors. In the current study, the potential anti-inflammatory activity of MP and EP was evaluated in different experimental rat models. Results showed that MP and EP caused reduction of carrageenan-induced rat paw edema in addition to diminishing prostaglandin E2 (PGE2) level in the inflammatory exudates. In lipopolysaccharide (LPS)-induced endotoxemia in rats, MP and EP reduced plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). MP and EP decreased NF-κB expression in liver and lung tissues and ameliorated histopathological changes caused by LPS. Topical application of MP and EP reduced ear edema induced by croton oil in rats. In the same animal model, MP and EP reduced neutrophil infiltration, as indicated by decreased myeloperoxidase (MPO) activity. In conclusion, this study demonstrates the effectiveness of MP and EP in combating inflammation in several experimental models.
棕榈酸甲酯（MP）和棕榈酸乙酯（EP）是天然存在的脂肪酸酯，被报道具有抑制炎症细胞的作用。在本研究中，评估了 MP 和 EP 在不同实验性大鼠模型中的潜在抗炎活性。结果表明，MP 和 EP 除了降低炎症渗出物中的前列腺素 E2（PGE2）水平外，还能减轻角叉菜胶诱导的大鼠足肿胀。在脂多糖（LPS）诱导的大鼠内毒素血症中，MP 和 EP 降低了肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的血浆水平。MP 和 EP 降低了肝和肺组织中 NF-κB 的表达，并改善了 LPS 引起的组织病理学变化。MP 和 EP 对大鼠巴豆油诱导的耳部水肿的局部应用可减少耳部水肿。在相同的动物模型中，MP 和 EP 减少了中性粒细胞浸润，如髓过氧化物酶（MPO）活性降低所表明的那样。总之，本研究证明了 MP 和 EP 在几种实验模型中对抗炎症的有效性。
