Malik Ajay, Veniyoor Ajit, Fanthome Barnard, Dutta Vibha
Department of Pathology, AFMC, Pune, India.
J Cancer Res Ther. 2012 Apr-Jun;8(2):306-7. doi: 10.4103/0973-1482.98998.
Follicular dendritic cell sarcoma (FDCS) is a spindle cell neoplasm of histiocytic-dendritic cells origin. It is known to occur in lymph nodes and rarely has been reported in extranodal tissues like head and neck, mediastinum and gastrointestinal tract. We herein report the first FDCS arising from anal canal in a 56-year-old man. The tumor was composed of bland short spindle cells in focal whorl formation with interspersed few lymphocytes. The tumor cells were classically positive for CD21, CD23, CD35 and vimentin. Despite its misleading morphology, immunohistochemistry helped us to reach a conclusive diagnosis for relevant therapy.
滤泡性树突状细胞肉瘤（FDCS）是一种起源于组织细胞-树突状细胞的梭形细胞瘤。已知其发生于淋巴结，而在结外组织如头颈部、纵隔和胃肠道中很少有报道。我们在此报告首例发生于一名56岁男性肛管的FDCS。肿瘤由温和的短梭形细胞组成，呈局灶性漩涡状排列，其间散在少量淋巴细胞。肿瘤细胞经典地表达CD21、CD23、CD35和波形蛋白。尽管其形态具有误导性，但免疫组织化学有助于我们做出明确诊断以进行相关治疗。
