Majumdar Kaushik, Sakhuja Puja, Kaur Sukhpreet, Rastogi Archana, Gondal Ranjana, Agarwal Anil
Department of Pathology, G B Pant Hospital, Jawaharlal Nehru Marg, New Delhi, India.
J Cancer Res Ther. 2012 Apr-Jun;8(2):317-9. doi: 10.4103/0973-1482.99004.
Inflammatory myofibroblastic tumor (IMT) has been described as a pseudosarcomatous proliferation of spindled myofibroblasts admixed with lymphoplasmacytic cells. The various terminologies like inflammatory pseudotumor, plasma cell granuloma, and inflammatory myofibrohistiocytic proliferation, used to describe this entity, highlight the controversial etiopathogenesis of this relatively indolent neoplasm. IMT has now been described in different anatomic locations. However, cases occurring in the gastrointestinal tract are rare with very few cases described in the appendix. We present a case of inflammatory myofibroblastic tumor appendix with mucosal dysplasia in a 41-year-old male, presenting with abdominal pain and lump in the right iliac fossa. Aspiration cytology yielded few atypical epithelial cells and spindle cells in a mucinous background, suggesting the possibility of pseudomyxoma peritonei. Awareness of IMT appendix with rare presence of mucosal dysplasia may help in preventing overzealous resection, especially in situations that on preoperative evaluation may suggest malignancy.
炎性肌纤维母细胞瘤（IMT）被描述为梭形肌纤维母细胞与淋巴细胞和浆细胞混合的假肉瘤样增殖。用于描述该实体的各种术语，如炎性假瘤、浆细胞性肉芽肿和炎性肌纤维组织细胞增殖，突出了这种相对惰性肿瘤有争议的病因学。IMT现已在不同解剖部位被描述。然而，发生在胃肠道的病例很少，阑尾中描述的病例极少。我们报告一例41岁男性阑尾炎性肌纤维母细胞瘤伴黏膜发育异常，表现为腹痛和右下腹肿块。抽吸细胞学检查在黏液背景中发现少量非典型上皮细胞和梭形细胞，提示腹膜假黏液瘤的可能性。认识到阑尾IMT伴罕见的黏膜发育异常可能有助于避免过度积极的切除，特别是在术前评估可能提示恶性肿瘤的情况下。
