Heart Centre and Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
Angiology. 2013 Aug;64(6):435-9. doi: 10.1177/0003319712454217. Epub 2012 Jul 26.
Although several studies have demonstrated the association between coronary artery calcification (CAC) and coronary artery disease events, the underlying mechanism has not been fully elucidated. Furthermore, extensive CAC still remains a poorly understood phenomenon. The objective of this study is to determine the clinical characteristics and differences between 831 asymptomatic individuals with very high CAC scores (CACS ≥ 1000) and 497 asymptomatic individuals with CAC scores of 400 to 999. Individuals with CACS ≥ 1000 were more likely to have hypertension ([HTN]; P = .0004), hypercholesterolemia (P = .0001), diabetes mellitus ([DM] P = .005), and high body mass index ([BMI]; P = .03) compared with individuals with CACS = 400-999. On multivariable analysis, age (P < .0001) and BMI (P = .01) were found to be significant risk factors for the presence of very high CAC. While for males, age (P < .0001), hypercholesterolemia (P = .001), DM (P = .002), and obesity (P = .003) were independent risk factors; in females only HTN (P = .04) was independent risk factor.
尽管有几项研究表明冠状动脉钙化 (CAC) 与冠状动脉疾病事件之间存在关联，但潜在的机制尚未完全阐明。此外，广泛的 CAC 仍然是一个尚未完全理解的现象。本研究的目的是确定 831 名无症状 CAC 评分非常高（CACS≥1000）个体和 497 名 CAC 评分 400-999 个体之间的临床特征和差异。CACS≥1000 的个体更容易患有高血压 ([HTN]；P =.0004)、高胆固醇血症 (P =.0001)、糖尿病 ([DM] P =.005) 和高身体质量指数 ([BMI]；P =.03)，与 CACS=400-999 的个体相比。多变量分析显示，年龄 (P<.0001) 和 BMI (P=.01) 是存在非常高 CAC 的显著危险因素。对于男性，年龄 (P<.0001)、高胆固醇血症 (P=.001)、DM (P=.002) 和肥胖 (P=.003) 是独立的危险因素；而女性只有 HTN (P=.04) 是独立的危险因素。
