已有钙化积分的无症状个体的冠状动脉钙化进展
Progression of coronary artery calcification in asymptomatic individuals with pre-existing calcium score.
作者信息
Koulaouzidis G, Charisopoulou D, Maffrett S, Tighe M, Jenkins P J, McArthur T
机构信息
Heart Centre and Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
出版信息
Int Angiol. 2013 Jun;32(3):327-31.
AIM
Coronary artery calcification (CAC) has been introduced as a reliable, non-invasive marker of atherosclerosis. In this retrospective study, we investigated the progression of CAC using electron beam computed tomography.
METHODS
The study enrolled 598 individuals (521 males; mean age: 59.3±8.3 years) with initial CAC score (CACS) ≥10. The mean interscan period was 2.4±1.35 years (range: 1-7 years). The mean CACS, for the entire cohort, was 262.4±423.9 at baseline scan and 380.3±547.6 at follow-up. The mean annualized progression in CACS was 57.7±123.7; 47.4±66.5 in females and 58.3±128.1 in males (P=0.46). The mean annualized progression in CACS was 39.6±61.3 in individuals <60 years and 75.7±161.5 in individuals >60 years (P=0.0003). In multivariate analysis, only baseline CACS (P<0.0001) and smoking (P=0.002) were independently associated with the annual change in CACS.
目的
冠状动脉钙化（CAC）已被视为动脉粥样硬化可靠的非侵入性标志物。在这项回顾性研究中，我们使用电子束计算机断层扫描研究了CAC的进展情况。
方法
该研究纳入了598名初始CAC评分（CACS）≥10的个体（521名男性；平均年龄：59.3±8.3岁）。平均扫描间期为2.4±1.35年（范围：1 - 7年）。整个队列在基线扫描时的平均CACS为262.4±423.9，随访时为380.3±547.6。CACS的平均年化进展为57.7±123.7；女性为47.4±66.5，男性为58.3±128.1（P = 0.46）。年龄<60岁个体的CACS平均年化进展为39.6±61.3，年龄>60岁个体为75.7±161.5（P = 0.0003）。在多变量分析中，只有基线CACS（P<0.0001）和吸烟（P = 0.002）与CACS的年度变化独立相关。
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