Drug delivery research center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
AAPS PharmSciTech. 2012 Sep;13(3):1024-30. doi: 10.1208/s12249-012-9827-y. Epub 2012 Jul 28.
Preparation of an intelligent drug delivery system which releases the drug in response to the environmental stimuli in a controlled manner is one of the interesting subjects and it is the purpose of this study. Films composed of Eudragit RS and different percentages of plasticizers (0%, 5%, 10%, or 20% w/w based on polymer weight), poly ethylene glycol 400 or triethyl citrate (TEC), were prepared by solvent casting method. Glass transition temperatures of the films were determined by differential scanning colorimetery. Water uptake and drug permeation through membranes with the glass transition temperature (Tg) close to the body temperature were investigated. Propranolol hydrochloride and acetaminophen were used as model drugs in permeation studies. The results showed that Eudragit RS films with 20% of either plasticizer showed thermo-responsivity around body temperature. The water uptake of the films and the permeation rates of both drugs increased at temperatures above the Tg of the films. The films containing TEC was found to be more appropriate thermo-responsive membrane due to a higher sensitivity to temperature and more ability to control drug release.
制备一种智能药物递送系统，使其能够响应环境刺激以控制方式释放药物，这是一个有趣的研究课题，也是本研究的目的。通过溶剂浇铸法制备了由 Eudragit RS 和不同百分比的增塑剂（基于聚合物重量的 0%、5%、10%或 20%w/w）、聚乙二醇 400 或柠檬酸三乙酯（TEC）组成的薄膜。通过差示扫描量热法测定了薄膜的玻璃化转变温度。研究了玻璃化转变温度（Tg）接近体温的膜的水吸收和药物渗透。盐酸普萘洛尔和对乙酰氨基酚被用作渗透研究的模型药物。结果表明，含有 20%增塑剂的 Eudragit RS 薄膜在体温附近表现出温敏性。在高于薄膜 Tg 的温度下，薄膜的吸水率和两种药物的渗透速率均增加。由于对温度更敏感且更能控制药物释放，因此含有 TEC 的薄膜是更合适的温敏性膜。
