Department of Oral Radiology, Osaka Dental University, 1-5-17, Otemae Chuo-ku, Osaka 540-0008, Japan.
J Radiat Res. 2012 Sep;53(5):722-6. doi: 10.1093/jrr/rrs027. Epub 2012 Jun 28.
To compare the effects of 60 Gy/10 fractions (twice a day) with those of 54 Gy/9 fractions in high-dose-rate interstitial brachytherapy (HDR-ISBT) for early tongue cancer, we performed a matched-pair analysis of patients with early tongue cancer (T1-2N0M0), who were treated with 60 or 54 Gy of radiation between 1996 and 2004. Seventeen patients treated with 54 Gy and 34 matched-pair patients treated with 60 Gy were extracted and analyzed. Local recurrence occurred in two patients in the 54-Gy arm and five patients in the 60-Gy arm. The 2-year local control rates were 88% for both the 54-Gy arm and 60-Gy arm (not significant). The 2-year overall survival rates were 88% in the 60-Gy arm and 82% in the 54-Gy arm. Two-year actuarial complication-free rates were 91% in the 60-Gy arm and 83% in the 54-Gy arm (not significant), respectively. There was no significant association between the total dose and local control rate and late complications. The outcome of 54 Gy/ 9 fractions was similar to that of 60 Gy/ 10 fractions in patients with early tongue cancer.
为了比较 60 Gy/10 次分割（每天两次）与高剂量率间质近距离治疗（HDR-ISBT）中 54 Gy/9 次分割治疗早期舌癌的效果，我们对 1996 年至 2004 年间接受 60 或 54 Gy 放疗的早期舌癌（T1-2N0M0）患者进行了配对分析。共提取并分析了 54 Gy 治疗的 17 例患者和 60 Gy 治疗的 34 对匹配患者。54 Gy 组有 2 例患者和 60 Gy 组有 5 例患者出现局部复发。54 Gy 组和 60 Gy 组的 2 年局部控制率分别为 88%（无显著性差异）。60 Gy 组和 54 Gy 组的 2 年总生存率分别为 88%和 82%。60 Gy 组 2 年无并发症生存率为 91%，54 Gy 组为 83%（无显著性差异）。总剂量与局部控制率和晚期并发症之间无显著相关性。对于早期舌癌患者，54 Gy/9 次分割的疗效与 60 Gy/10 次分割相似。
