James Fiona M K, da Costa Ronaldo C, Fauber Amy, Peregrine Andrew S, McEwen Beverly, Parent Joane M, Bergman Robert
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
J Am Anim Hosp Assoc. 2012 Sep-Oct;48(5):331-8. doi: 10.5326/JAAHA-MS-5774. Epub 2012 Jul 27.
One spayed female Labrador retriever and two castrated male golden retrievers were evaluated for chronic (i.e., ranging from 3 wk to 24 wk) neurologic signs localizable to the prosencephalon. Signs included seizures, circling, and behavior changes. MRI demonstrated extra-axial, contrast-enhancing, multiloculated, fluid-filled, cyst-like lesions with a mass effect, causing compression and displacement of brain parenchyma. Differential diagnoses included cystic neoplasm, abscess or other infectious cyst (e.g., alveolar hydatid cyst), or fluid-filled anomaly (e.g., arachnoid cyst). The cyst-like lesions were attached to the rostral falx cerebri in all cases. In addition, case 2 had a second polycystic mass at the caudal diencephalon. Surgical biopsy (case 3 with a single, rostral tumor via transfrontal craniectomy) and postmortem histology (in cases 1 and 2) confirmed polycystic meningiomas. Tumor types were transitional (cases 1 and 3) and fibrous (case 2), with positive immunohistochemical staining for vimentin. Case 3 was also positive for E-cadherin, s100, and CD34. In all cases, staining was predominantly negative for glial fibrillary acid protein and pancytokeratins, supporting a diagnosis of meningioma. This report describes the first cases of polycystic meningiomas in dogs. Polycystic meningiomas are a rare, but important, addition to the differential diagnoses for intracranial cyst-like lesions, significantly affecting planning for surgical resection and other therapeutic interventions.
对一只已绝育的雌性拉布拉多猎犬和两只去势的雄性金毛寻回犬进行了评估，它们患有可定位于前脑的慢性（即3周龄至24周龄）神经症状。症状包括癫痫发作、转圈和行为改变。磁共振成像（MRI）显示轴外、有对比增强、多房、充满液体的囊肿样病变，并伴有占位效应，导致脑实质受压和移位。鉴别诊断包括囊性肿瘤、脓肿或其他感染性囊肿（如肺泡包虫囊肿）或充满液体的异常（如蛛网膜囊肿）。所有病例中，囊肿样病变均附着于大脑镰前部。此外，病例2在间脑尾部还有第二个多囊性肿块。手术活检（病例3通过经额开颅术切除单个前部肿瘤）和尸检组织学检查（病例1和2）证实为多囊性脑膜瘤。肿瘤类型为过渡型（病例1和3）和纤维型（病例2），波形蛋白免疫组化染色呈阳性。病例3的E-钙黏蛋白、S100和CD34也呈阳性。在所有病例中，胶质纤维酸性蛋白和全细胞角蛋白染色主要为阴性，支持脑膜瘤的诊断。本报告描述了犬多囊性脑膜瘤的首例病例。多囊性脑膜瘤是颅内囊肿样病变鉴别诊断中一种罕见但重要的疾病，对手术切除和其他治疗干预的规划有重大影响。
