Han Sunkyu, Siegel Dustin S, Movassaghi Mohammad
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tetrahedron Lett. 2012 Jul 18;53(29):3722-3726. doi: 10.1016/j.tetlet.2012.04.121. Epub 2012 May 2.
The lithiation and electrophilic substitution of dimethyl triazones is described. Directed lithiation or tin-lithium exchange of dimethyl triazones afforded the corresponding dipole stabilized nucleophiles that were trapped with various electrophiles. Keto-triazone derivatives accessed by acylation of such nucleophiles were readily converted to the corresponding imidazolone heterocycles.
描述了二甲基三氮烯的锂化和亲电取代反应。二甲基三氮烯的定向锂化或锡-锂交换反应得到了相应的偶极稳定亲核试剂，这些亲核试剂能被各种亲电试剂捕获。通过此类亲核试剂的酰化反应得到的酮基三氮烯衍生物很容易转化为相应的咪唑酮杂环化合物。
