从富含铁的天然泉水中发现的微生物席中分离出的真菌所产生的次生代谢产物。
Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring.
作者信息
Gerea Alexandra L, Branscum Katie M, King Jarrod B, You Jianlan, Powell Douglas R, Miller Andrew N, Spear John R, Cichewicz Robert H
机构信息
Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center 101 Stephenson Parkway, Room 1000, University of Oklahoma, Norman, Oklahoma, 73019-5251, USA.
出版信息
Tetrahedron Lett. 2012 Aug 8;53(32):4202-4205. doi: 10.1016/j.tetlet.2012.05.156. Epub 2012 Jun 8.
Abstract
A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possible Entrophospora sp.) and a Dothideomycete (possible Phaeosphaeria sp.), were investigated for bioactive secondary metabolites. In total, six new compounds consisting of clearanols A-E (5, 6, 10-12) and disulochrin (7) were purified and their structures were determined. Disulochrin exhibited modest antibacterial activity against methicillin-resistant Staphylococcus aureus, whereas clearanol C showed weak inhibitory activity against Candida albicans biofilm formation.
摘要
从一个复杂的微生物垫中获取了一组真菌分离物，该微生物垫位于美国科罗拉多州戈尔登市清澈溪的一个富含铁的淡水泉中。对其中两种真菌分离物进行了生物活性次级代谢产物研究，一种是球囊菌门真菌（可能是内养囊霉属），另一种是座囊菌纲真菌（可能是暗球腔菌属）。总共纯化出了六种新化合物，分别为清澈醇A - E（5、6、10 - 12）和双硫色菌素（7），并确定了它们的结构。双硫色菌素对耐甲氧西林金黄色葡萄球菌表现出适度的抗菌活性，而清澈醇C对白色念珠菌生物膜形成显示出微弱的抑制活性。
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