1例小细胞肺癌患者在接受氨柔比星治疗期间虽进行了预防性颅脑照射仍发生癌性脑膜炎。
A case of carcinomatous meningitis despite prophylactic cranial irradiation in small cell lung cancer during treatment with amrubicin.
作者信息
Oguri Tetsuya, Uemura Takehiro, Kunii Eiji, Ozasa Hiroaki, Ohkubo Hirotsugu, Miyazaki Mikinori, Maeno Ken, Sato Shigeki
机构信息
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
出版信息
Oncol Lett. 2012 Aug;4(2):305-306. doi: 10.3892/ol.2012.725. Epub 2012 May 22.
A 47-year-old man was diagnosed with limited-disease small cell lung cancer. Treatment was initiated with concurrent chemotherapy and radiotherapy. A partial response was achieved, and prophylactic cranial irradiation (PCI) was administered. Local recurrence was identified on follow-up and treated with amrubicin (AMR). After two courses of AMR, a state of stable disease was achieved and AMR treatment was continued. After the third course of AMR, the patient was urgently hospitalized suffering from a headache and disturbance of consciousness, and a diagnosis of carcinomatous meningitis was made. This case report concerns a case of carcinomatous meningitis despite PCI during treatment with AMR.
一名47岁男性被诊断为局限性小细胞肺癌。开始采用同步放化疗进行治疗。获得了部分缓解，并给予了预防性颅脑照射（PCI）。随访时发现局部复发，遂用氨柔比星（AMR）进行治疗。两个疗程的AMR治疗后病情稳定，继续使用AMR治疗。第三个疗程的AMR治疗后，患者因头痛和意识障碍紧急住院，诊断为癌性脑膜炎。本病例报告涉及1例在接受AMR治疗期间尽管进行了PCI仍发生癌性脑膜炎的病例。
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