化疗耐药的生化基础。

Biochemical basis of resistance to chemotherapy.

作者信息

Masters J R

机构信息

Institute of Urology, University College London, St. Pauls Hospital, U.K.

出版信息

Radiother Oncol. 1990 Dec;19(4):297-305. doi: 10.1016/0167-8140(90)90029-v.

DOI:10.1016/0167-8140(90)90029-v

PMID:2284441

Abstract

Recent progress in the understanding of drug resistance has led to the discovery of new targets for chemotherapy. By attacking the molecules that make cancer cells insensitive to chemotherapy, it is hoped that drug-resistant disease will respond to treatment. This review describes some of the latest advances in understanding of the biochemistry of drug resistance. Following a general introduction four areas of topical interest are discussed: (1) multidrug resistance and P-glycoprotein, (2) glutathione and its related enzymes, (3) topoisomerase II and (4) DNA repair.

摘要

在耐药性认识方面的最新进展已促成了化疗新靶点的发现。通过攻击那些使癌细胞对化疗不敏感的分子，有望使耐药性疾病对治疗产生反应。本综述描述了在耐药性生物化学认识方面的一些最新进展。在进行一般性介绍之后，将讨论四个当前备受关注的领域：（1）多药耐药性与P-糖蛋白，（2）谷胱甘肽及其相关酶，（3）拓扑异构酶II，以及（4）DNA修复。