Corcos D
Institut Jacques Monod du CNRS, Unité INSERM 257, Université, Paris VII.
Res Immunol. 1990 Jul-Aug;141(6):543-53. doi: 10.1016/0923-2494(90)90022-q.
Some growth factor receptor genes can be activated to become oncogenic as a result of various mutations. The receptors that are encoded by these genes may deliver constitutive signals independent of ligand binding. The model which is presented here assumes that alterations in the B-cell antigen receptor could have similar effects. Evidence that membrane immunoglobulin alterations contribute to oncogenesis in vivo comes from studies of heavy chain diseases. Moreover, this model could have also implications for other B-cell neoplasias.
一些生长因子受体基因可因各种突变而被激活成为致癌基因。这些基因编码的受体可能传递不依赖配体结合的组成性信号。此处提出的模型假定B细胞抗原受体的改变可能有类似作用。膜免疫球蛋白改变在体内促成肿瘤发生的证据来自对重链病的研究。此外，该模型可能也与其他B细胞肿瘤形成有关。
