Bro F
Institute of General Practice, University of Aarhus, Denmark.
Scand J Prim Health Care. 1990 Dec;8(4):219-23. doi: 10.3109/02813439008994962.
In a randomized, double-blind clinical trial from general practice, 500 mg metronidazole pessaries applied once daily for seven days were compared with placebo in the treatment of bacterial vaginosis. Seventy-five women completed the study. At the follow-up visit immediately after completion of treatment, none of the patients on metronidazole fulfilled the criteria for bacterial vaginosis, compared with 12 (35%) in the placebo group (p less than 0.001). Nine (22%) of the patients treated with metronidazole harboured Gardnerella vaginalis after treatments, compared with 31 (91%) in the placebo group (p less than 0.001). Symptoms had improved or disappeared in 33 (80%) on metronidazole, and in 18 (53%) on placebo therapy (p less than 0.05). Four weeks after the follow-up visit, symptoms were reported by 28% in the metronidazole group and by 44% in the placebo group (p greater than 0.05). Metronidazole pessaries are effective in the treatment of bacterial vaginosis.
在一项来自普通医疗实践的随机双盲临床试验中，将每日一次应用500毫克甲硝唑阴道栓剂共七天的治疗方案与安慰剂用于细菌性阴道病的治疗进行比较。75名女性完成了该研究。在治疗结束后立即进行的随访中，甲硝唑治疗组的患者均未达到细菌性阴道病的标准，而安慰剂组有12名患者（35%）达到该标准（p<0.001）。接受甲硝唑治疗的患者中有9名（22%）在治疗后携带阴道加德纳菌，而安慰剂组有31名（91%）（p<0.001）。甲硝唑治疗组中33名患者（80%）的症状改善或消失，安慰剂治疗组中18名患者（53%）症状改善或消失（p<0.05）。随访四周后，甲硝唑组28%的患者报告有症状，安慰剂组为44%（p>0.05）。甲硝唑阴道栓剂对细菌性阴道病有效。
