Perry Christina J, McNally Gavan P
School of Psychology, The University of New South Wales, Sydney, Australia.
Behav Neurosci. 2012 Aug;126(4):599-604. doi: 10.1037/a0029079.
Opioid receptors are involved in reinstatement of alcohol seeking, yet there are no reports of their role in reacquisition of an extinguished alcohol seeking response. Here we investigated the effects of the opioid antagonist naloxone on reacquisition and compared these effects with those on acquisition. Rats were trained, extinguished, then retrained to respond for alcoholic beer. Upon retraining, a second group of rats with no prior experience with the contingency between response and reinforcer was trained under the same conditions. Reacquisition was faster than acquisition. Systemic injection of naloxone (1.25 or 5 mg/kg) reduced reacquisition but had no effect on acquisition. These results suggest that reacquisition and acquisition of alcohol seeking have dissociable neurochemical substrates.
阿片受体参与了觅酒行为的恢复，但尚无关于它们在已消退的觅酒反应重新习得过程中作用的报道。在此，我们研究了阿片拮抗剂纳洛酮对重新习得的影响，并将这些影响与对习得的影响进行了比较。大鼠先接受训练、消退训练，然后再次训练以对酒精啤酒做出反应。在重新训练时，将第二组之前没有经历过反应与强化物之间关联性的大鼠在相同条件下进行训练。重新习得比习得更快。全身注射纳洛酮（1.25或5毫克/千克）会降低重新习得，但对习得没有影响。这些结果表明，觅酒行为的重新习得和习得具有可分离的神经化学底物。
