Genc Gurkan, Ozkaya Ozan, Aygun Canan, Yakupoglu Yarkin Kamil, Nalcacioglu Hulya
Pediatric Nephrology Department, Ondokuzmayis University Faculty of Medicine, Children's Hospital, Samsun, Turkey.
Exp Clin Transplant. 2012 Aug;10(4):314-8. doi: 10.6002/ect.2012.0059.
Infectious diseases, even vaccine preventable ones, might affect transplanting and the life course in pediatric solid-organ recipients. Owing to immunosuppression and decreased antibody production, susceptibility to infections is increased in these patients.
The present study was designed to assess the vaccination and antibody status of the pediatric renal transplant patients. Fifty-one patients who were admitted to the regional transplant center for renal transplant were retrospectively evaluated. Patient 's vaccination charts were examined, and their immunization status was determined by antibody titers against hepatitis B, hepatitis A, measles, mumps, rubella, and varicella.
The study group was composed of 23 males and 28 females (mean age, 10.8 y; age range, 2-17 y). All patients ' vaccination status was appropriate with their ages according to national vaccination program. Antibodies were positive for hepatitis B in 84.3% patients, 76.5% for hepatitis A, 72.5% for measles, 64.7% for mumps, 64.7% for rubella, and 72.5% for varicella.
Seronegativity for common childhood diseases may complicate the posttransplant period owing to increased risk of infections. Especially in developing countries, immunization protocols and vaccination program schedules should be reviewed before transplant to prevent serious complications caused by these diseases.
传染病，即使是可通过疫苗预防的传染病，也可能影响小儿实体器官移植受者的移植及生命历程。由于免疫抑制和抗体产生减少，这些患者对感染的易感性增加。
本研究旨在评估小儿肾移植患者的疫苗接种及抗体状况。对51名入住地区移植中心进行肾移植的患者进行回顾性评估。检查患者的疫苗接种记录，并通过检测针对乙型肝炎、甲型肝炎、麻疹、腮腺炎、风疹和水痘的抗体滴度来确定其免疫状态。
研究组由23名男性和28名女性组成（平均年龄10.8岁；年龄范围2至17岁）。根据国家疫苗接种计划，所有患者的疫苗接种状况与其年龄相符。84.3%的患者乙型肝炎抗体呈阳性，甲型肝炎为76.5%，麻疹为72.5%，腮腺炎为64.7%，风疹为64.7%，水痘为72.5%。
常见儿童疾病的血清阴性可能因感染风险增加而使移植后时期复杂化。特别是在发展中国家，移植前应审查免疫方案和疫苗接种计划时间表，以预防这些疾病引起的严重并发症。
