Chemical Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research, Adyar, Chennai 600 020, India.
Eur J Med Chem. 2012 Nov;57:449-58. doi: 10.1016/j.ejmech.2012.06.039. Epub 2012 Jul 16.
Three mononuclear copper(II) complexes, [Cu(tpy)Cl(2)] 1, [Cu(tpy)(NO(3))(2)(H(2)O)] 2 and [Cu(Ptpy)Cl(2)]·H(2)O·HCl 3 have been synthesised and characterized by various spectroscopic techniques and single crystal X-ray diffraction. Complexes 1 and 3 have five coordinate geometry in solid state, whereas complex 2 has six coordinate geometry. Mass spectral and EPR evidence suggest that in solution all the three complexes exist predominantly as a four coordinate species. Molecular modelling and DNA cleavage studies indicate that complexes 1 and 2 are DNA minor groove binders, whereas 3 is an intercalator. All the three complexes show nuclease activity in the presence of hydrogen peroxide. The three complexes have been found to be cytotoxic towards A549 lung adenocarcinoma cells.
三种单核铜（II）配合物，[Cu(tpy)Cl(2)] 1，[Cu(tpy)(NO(3))(2)(H(2)O)] 2 和 [Cu(Ptpy)Cl(2)]·H(2)O·HCl 3 已通过各种光谱技术和单晶 X 射线衍射进行了合成和表征。配合物 1 和 3 在固态中具有五配位几何构型，而配合物 2 具有六配位几何构型。质谱和 EPR 证据表明，在溶液中，所有三种配合物主要以四配位物种存在。分子建模和 DNA 切割研究表明，配合物 1 和 2 是 DNA 小沟结合物，而 3 是嵌入剂。所有三种配合物在过氧化氢存在下均显示出核酸酶活性。这三种配合物已被发现对 A549 肺腺癌细胞具有细胞毒性。
