中脑边缘多巴胺神经元损伤对大鼠痛阈及吗啡镇痛的影响。

The effects of lesion of mesolimbic dopamine neurons on pain threshold and morphine analgesia in rats.

作者信息

Szreniawski Z, Mészáros J, Gajewska S, Tarchalska-Kryńska B

出版信息

Pol J Pharmacol Pharm. 1977 Sep-Oct;29(5):521-5.

PMID:22847

Abstract

Lesions of ventral tegmental area, localised in the region of A 10 group of dopaminergic mesolimbic neurons decreased the pain threshold in rats. The absolute threshold values in morphine treated animals with the above lesion were lower than in sham-operated controls, however, the thresholds expressed as percentage of predrug threshold values did not differ in both lesioned and sham-operated animals. It is thought, that lesions of ventral tegmental dopamine neurons decrease the pain threshold due to the increase of general excitability of animals, and that there is no direct involvement of the lesioned structure in the primary mechanism of morphine analgesia.

摘要

腹侧被盖区的损伤，定位于A10组多巴胺能中脑边缘神经元区域，降低了大鼠的痛阈。在患有上述损伤的吗啡治疗动物中，绝对阈值低于假手术对照组，然而，以给药前阈值百分比表示的阈值在损伤组和假手术组动物中并无差异。据认为，腹侧被盖区多巴胺神经元的损伤由于动物总体兴奋性增加而降低了痛阈，并且损伤结构在吗啡镇痛的主要机制中没有直接参与。

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