Borisova A M, Koev D, Kirilov G
Vutr Boles. 1990;29(3):74-8.
In high degree obesity there a significantly smaller area under the curve of C-peptide after stimulation with Tolbutamide and significantly lower insulin sensitivity measured in vivo by euglycemic hyperinsulinemic clamp-technique (Biostator) than in moderate obesity. This allows the conclusion that high degree obesity is a risk factor for the development of diabetes mellitus.
在高度肥胖患者中，用甲苯磺丁脲刺激后C肽曲线下面积显著小于中度肥胖患者，并且通过正常血糖高胰岛素钳夹技术（生物调节器）在体内测得的胰岛素敏感性也显著低于中度肥胖患者。由此可以得出结论，高度肥胖是糖尿病发生的一个危险因素。
