Liu Mingli, Guo Shanchun, Stiles Jonathan K
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.
Oncol Lett. 2011 Jul;2(4):583-589. doi: 10.3892/ol.2011.300. Epub 2011 May 9.
The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 is involved in chemotaxis, induction of apoptosis, regulation of cell growth and mediation of angiostatic effects. CXCL10 is associated with a variety of human diseases including infectious diseases, chronic inflammation, immune dysfuntion, tumor development, metastasis and dissemination. More importantly, CXCL10 has been identified as a major biological marker mediating disease severity and may be utilized as a prognostic indicator for various diseases. In this review, we focus on current research elucidating the emerging role of CXCL10 in the pathogenesis of cancer. Understanding the role of CXCL10 in disease initiation and progression may provide the basis for developing CXCL10 as a potential biomarker and therapeutic target for related human malignancies.
趋化因子γ干扰素诱导蛋白10 kDa（CXCL10）是CXC趋化因子家族的成员，它与CXCR3受体结合以发挥其生物学效应。CXCL10参与趋化作用、诱导细胞凋亡、调节细胞生长以及介导血管生成抑制效应。CXCL10与多种人类疾病相关，包括传染病、慢性炎症、免疫功能障碍、肿瘤发生、转移和扩散。更重要的是，CXCL10已被确定为介导疾病严重程度的主要生物学标志物，并可作为各种疾病的预后指标。在本综述中，我们聚焦于当前阐明CXCL10在癌症发病机制中新兴作用的研究。了解CXCL10在疾病发生和进展中的作用可能为将CXCL10开发成相关人类恶性肿瘤的潜在生物标志物和治疗靶点提供依据。
