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[磷酸肽在脑组织氧化氨基酸交换中的作用]

[Participation of phosphopeptides in oxidative amino acid exchange in brain tissue].

作者信息

Kometiani P A, Edilashvili L A, Mikeladze D G

出版信息

Vopr Biokhim Mozga. 1978;13:158-67.

PMID:228489
Abstract

Specific proteins and phosphopeptides of nervous tissue soluble in acidified organic solvents have been shown to have an active participation in the metabolism of ammonia. Nitrogen phosphopeptides (amides) bound to phosphate residues which are non stable in acids. It was shown that acid-labil nitrogen (amide group) of phosphopeptides, bound to phosphate risidue, participates in the metabolism of ammonia formed during the oxidative deamination of amino acids. The data obtained indicate that 3'--5'-AMP dependent proteinkinase participates in the phosphorilation of phosphopeptides.

摘要

已证明可溶于酸化有机溶剂的神经组织特异性蛋白质和磷酸肽积极参与氨的代谢。与在酸中不稳定的磷酸残基结合的氮磷酸肽(酰胺)。结果表明,与磷酸残基结合的磷酸肽的酸不稳定氮(酰胺基)参与氨基酸氧化脱氨过程中形成的氨的代谢。所获得的数据表明,3'-5'-AMP依赖性蛋白激酶参与磷酸肽的磷酸化。

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