诊断时血小板计数正常的急性白血病。

Acute leukemia with normal platelet count at diagnosis.

作者信息

Hara T, Mizuno Y, Ikuno Y, Okamura J, Nagata M, Ishii E, Yamada S, Tasaka H, Ueda K

机构信息

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Acta Paediatr Jpn. 1990 Oct;32(5):515-8. doi: 10.1111/j.1442-200x.1990.tb00872.x.

DOI:10.1111/j.1442-200x.1990.tb00872.x

PMID:2284928

Abstract

Thirty-six (17.8%) of 202 children with acute lymphoblastic leukemia (ALL) and 2 (3.7%) of 54 children with acute nonlymphoblastic leukemia (ANLL) had a platelet count over 150 x 10(9)/l at diagnosis. Children with ALL and a platelet count over 150 x 10(9)/l were analysed in detail. The ALL patients without thrombocytopenia tended to be male predominant and had less frequent bleeding manifestations (p less than 0.01). These patients without thrombocytopenia had also significantly less marked leukocytosis (p less than 0.01), less severe anemia (p less than 0.05) and lower percentages of bone marrow blasts (p less than 0.05) than those with thrombocytopenia. In addition, ALL patients without thrombocytopenia had a significantly higher probability of continuous complete remission than those with thrombocytopenia (p less than 0.01).

摘要

202例急性淋巴细胞白血病（ALL）患儿中，36例（17.8%）在诊断时血小板计数超过150×10⁹/L；54例急性非淋巴细胞白血病（ANLL）患儿中，2例（3.7%）在诊断时血小板计数超过150×10⁹/L。对血小板计数超过150×10⁹/L的ALL患儿进行了详细分析。无血小板减少的ALL患者男性居多，出血表现较少（p<0.01）。与有血小板减少的患者相比，这些无血小板减少的患者白细胞增多也明显较少（p<0.01），贫血较轻（p<0.05），骨髓原始细胞百分比更低（p<0.05）。此外，无血小板减少的ALL患者持续完全缓解的概率明显高于有血小板减少的患者（p<0.01）。