Hu Q L, Wang H, Wang Y S, Chen R X, Shen W M
Department of Microbiology and Immunology, West China University of Medical Sciences, Chengdu.
Yao Xue Xue Bao. 1990;25(5):326-9.
The effects of a novel antitumor antibiotic polyactin A (PA) on in vitro IL-2 production and IL-2 responsiveness of human lymphocytes were investigated. The results show that PA in a concentration range from 0.01 to 100 micrograms/ml obviously augmented in vitro IL-2 production, IL-2 receptor expression and responsiveness to IL-2 of human lymphocytes in the presence of PHA, and that these enhancing effects of PA were dose-dependent. The results demonstrated the potentiating effect of PA on cellular immunity and suggested the suitable use of PA in clinical treatment of tumors. The possible application of PA to the treatment of immune disorders involving deficiency of IL-2 production and/or IL-2 responsiveness of lymphocytes is also considered.
研究了一种新型抗肿瘤抗生素多杀菌素A（PA）对人淋巴细胞体外白细胞介素-2（IL-2）产生及IL-2反应性的影响。结果表明，在0.01至100微克/毫升的浓度范围内，PA在有植物血凝素（PHA）存在的情况下，可显著增强人淋巴细胞的体外IL-2产生、IL-2受体表达及对IL-2的反应性，且PA的这些增强作用呈剂量依赖性。结果证明了PA对细胞免疫的增强作用，并提示PA在肿瘤临床治疗中的合理应用。还考虑了PA在治疗涉及淋巴细胞IL-2产生不足和/或IL-2反应性的免疫紊乱中的可能应用。
