4-（3-氨基-4-取代苯基-2-氧代氮杂环丁烷-1-基）甲基-环己烷羧酸和苯甲酸的合成及其对β-内酰胺酶的抑制作用
[Synthesis and inhibition on beta-lactamase of 4-(3-amido-4-substituted phenyl-2-oxo-azetidinonyl-1)methyl-cyclohexane carboxylic acids and -benzoic acids].
作者信息
Yin S F, Mao W R
机构信息
School of Pharmacy, West China University of Medical Sciences, Chengdu.
出版信息
Yao Xue Xue Bao. 1990;25(5):340-4.
PMID:2284952
Abstract
Eleven title compounds have been synthesized from trans-4-amino-methyl-cyclohexylic acid and 4-aminomethyl-benzoic acid, and were identified via elemental analysis, IR, 1HMNR and MS. Their beta-lactamase inhibition activity was determined and contrasted with penicillanic acid S-dioxide. The results of the preliminary test show that all the products have beta-lactamase inhibition activity to some extent.
摘要
已由反式-4-氨甲基环己基酸和4-氨甲基苯甲酸合成了11种标题化合物，并通过元素分析、红外光谱、核磁共振氢谱和质谱对其进行了鉴定。测定了它们的β-内酰胺酶抑制活性，并与青霉烷酸S-二氧化物进行了对比。初步试验结果表明，所有产物都具有一定程度的β-内酰胺酶抑制活性。
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