[WB852与β-环糊精包合物的研究]
[A study of the inclusion complex of WB852 with beta-cyclodextrin].
作者信息
Wang S L, Su D S, Ji Z Z
机构信息
Shenyang College of Pharmacy.
出版信息
Yao Xue Xue Bao. 1990;25(6):477-80.
The aim of this study was to increase the stability of WB852 in aqueous solution by inclusion complex formation with beta-cyclodextrin (beta-CD). The stability of WB852-beta-CD in aqueous solution was determined. The hydrolysis rate of WB852 from the inclusion compound was lower than that of WB852 alone. The solid inclusion compound of WB852 with beta-CD in 1:3 molar ratio was prepared by the freeze-drying method. The formation of an inclusion compound with beta-CD in solid state was confirmed by X-ray diffractometry, IR spectroscopy and differential thermal analysis (DTA).
本研究的目的是通过与β-环糊精（β-CD）形成包合物来提高WB852在水溶液中的稳定性。测定了WB852-β-CD在水溶液中的稳定性。包合物中WB852的水解速率低于单独的WB852。采用冷冻干燥法制备了摩尔比为1:3的WB852与β-CD的固体包合物。通过X射线衍射、红外光谱和差示热分析（DTA）证实了固态下与β-CD形成了包合物。
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