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Extrasynaptic site of action for γ-hydroxybutyrate.

作者信息

Enna S J

机构信息

Department of Molecular and Integrative Physiology, University of Kansas Medical School, Kansas City, KS 66160, USA.

出版信息

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13142-3. doi: 10.1073/pnas.1210290109. Epub 2012 Jul 31.

Abstract
摘要

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本文引用的文献

1
α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB).
Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13404-9. doi: 10.1073/pnas.1204376109. Epub 2012 Jul 2.
2
Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.
J Neurophysiol. 2011 Oct;106(4):2057-64. doi: 10.1152/jn.00450.2011. Epub 2011 Jul 27.
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γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB.
J Neurochem. 2010 Oct;115(1):58-67. doi: 10.1111/j.1471-4159.2010.06901.x.
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Enhanced tonic GABAA inhibition in typical absence epilepsy.
Nat Med. 2009 Dec;15(12):1392-8. doi: 10.1038/nm.2058. Epub 2009 Nov 22.
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Extrasynaptic GABAA receptors: form, pharmacology, and function.
J Neurosci. 2009 Oct 14;29(41):12757-63. doi: 10.1523/JNEUROSCI.3340-09.2009.
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Challenges in the search for drugs to treat central nervous system disorders.
J Pharmacol Exp Ther. 2009 May;329(2):404-11. doi: 10.1124/jpet.108.143420. Epub 2009 Jan 30.
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Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain.
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